Toxicology: Open Access
Open Access

Abstract

Psychotic disorders are severe mental disorders that cause abnormal thinking and perceptions. Antipsychotic drug treatment is a key component of schizophrenia treatment first-generation antipsychotics, known as typical antipsychotics where second-generation drugs, known as atypical antipsychotics. All psychotropic medications have the potential to induce numerous and diverse unwanted ocular effects. The study aimed to assess the occurrence of ocular toxic effects of antipsychotic drugs and evaluate intraocular pressure in patients treated with psychiatric medications. Informed consent was taken from patients. The present study was conducted on 100 chronic psychotic patients attending the Alexandria main university hospital who on treatment of antipsychotic drugs for a period more than six months period with age group between18-45 years. 14% of those patients were on phenothiazine therapy, 16% on atypical anti-psychotic while 70% were on combined therapy. 2% of all cases had pigmentation of conjunctiva that was on phenothiazine therapy only. Corneal opacity was manifested on 5% of cases. The majority of them was on phenothiazine therapy only while 14% on combined therapy. 7% was suffered from lens opacity; six cases due to phenothiazine therapy only while one case due to combined therapy. Intraocular pressure was manifested in 11% of all cases. Optic examination revealed two cases had increased cup disc ratio who on phenothiazine therapy only. It was concluded that ocular toxicity was manifested mainly with phenothiazine therapy that affected by duration of treatment. The incidence of toxicity decreased with combination of typical and atypical. It is recommended that psychiatrists, ophthalmologists and patients need to be aware of and prepared for any medication-induced ocular toxic effect. wafaaelsehly@gmail.com

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