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Oxidative stress and cardiometabolic syndrome in Algerian hypertensive subject: Impact of Copper/zinc ratio as endothelial dysfunction predictive biomarker
4th International Conference and Exhibition on Obesity and Weight Management
Ines Gouaref 1, B Alamir3, Z Bellahsene2 and E A Koceir1
1University of Science and Technology Houari Boumediene, Algeria 2EPH-Hopital d� Birtraria El Biar, Algeria 3CHU de Bab El Oued, Algeria
Posters-Accepted Abstracts: J Obes Weight Loss Ther
Abstract
Objective: In the systemic hypertension (SHT), the relationship between antioxidants mineral trace elements (AMTE) is very complex during oxidative stress, being mediated by endothelial dysfunction, dyslipidemia and inflammation. We investigated the AMTE status, particularly Manganese, selenium, copper and Zinc on the SHT control and their interaction with the cardiometabolic syndrome (CMS) clusters. Design & Method: The study was undertaken on 278 Algerian hypertensive subjects who were divided in 2 groups according to systolic blood pressure (SBP) <140 or >140 mmHg value and diastolic blood pressure (DBP) <90 or >90 mmHg value; attesting for a good or poor metabolic control of SHT, respectively. The CMS was defined according to NCEP-ATPIII. Insulin resistance was evaluated by HOMA-IR model. The blood AMTE, were evaluated by atomic mass spectrometry. Results: The AMTE status showed that hypertensive patients with CMS are mainly depleted. The selenium was positively correlated with glutathion peroxidase activity. The copper and Zinc are increased, causing an increase in the ratio Cu/Zn associated to decrease the SOD activity. Conclusion: Our results suggest that AMTE play a crucial role in antioxidant capacity in SHT and we hypothesize that antioxidant defense is impaired in mitochondria, which makes this cell organelle a true therapeutic target in SHT. The AMTE can be considered as an insidious biomarkers endothelial dysfunction.Biography
Ines Gouaref is conducting her Phd Thesis on the link between trace elements, type 2 diabetes and hypertension in the University of Science and Technology Houari Boumediene, Algiers, Algeria. She started her Phd thesis in 2011 and participated in too many national and international scientific events to present her conclusions on the diabetes in Algeria, North Africa.
Email: igouaref@gmail.com
