Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Omental adipose removal decreases high blood pressure in hypertensive patients independent of body mass index: It is a multicenter, prospective cohort clinical study. 133 patients with gastric or gynecological cancer were divided into three groups: non-hypertensive and omentum removed (NH&OR), hypertensive and omentum removed (H&OR), and hypertensive and omentum present (H&OP). The patients were followed up in sitting blood pressure (SBP), changes in related body mass index and metabolic indices. The time points of the two follow-up visits were one month±7 days after the operation before the start of chemotherapy and the endpoint of 8±1 month. H&OR group showed significant reductions in SSBP and SDBP at 1-m (-16.94/-10.50 mmHg, both P<0.001) and 8-m endpoint (-16.00/-5.50 mmHg, P<0.001 and P=0.004). Little reductions were observed with BMI of patients in three groups (H&OR group: 24.60 kg/m2 to 23.57 kg/m2, NH&OR group: 23.45 kg/m2 to 23.25 kg/m2, H&OP group: 25.74 kg/m2 to 25.24 kg/m2, all P>0.05). No correlation was found between baseline BMI and 8-m change of SSBP and SDBP in H&OR groups. In both groups, triglyceride levels were significantly increased at 1-m after surgery (NH&OR 0.32 mmol/L, P=0.006; H&OR 0.40 mmol/L, P=0.010). Resection of omental adipose tissue represents an impact for reducing SSBP and SDBP at eight months in hypertensive patients, even in the non-obese hypertensive population.

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