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Novel quinazoline compound-induced apoptotic cell death in 5FU-resistant HT29 cells
8th World Congress on Toxicology and Pharmacology
Je-Wei Tsao, Mann-Jen Hour and Jai-Sing Yang
China Medical University, Taiwan
Posters & Accepted Abstracts: Toxicol Open Access
Abstract
In this study, Novel Quinazoline Compound (NQC) suppressed viability in 5FU-resistant HT29 cells through inhibiting cell proliferation, causing cell cycle arrest and triggering apoptosis. Flow cytometry analysis revealed that NQC caused 5FUresistant HT29 cell cycle arrest at G2/M phase and increased the proportion of polyploidy cells. Western blotting indicated that the expression of cyclin B1, p-Cdk1 and Cdk1 increased after treatment with NQC. Colorimetric assay analyses also showed that activities of caspase-3, caspase-8 and caspase-9 occurred in NQC-treated 5FU-resistant HT29 cells. Together, these results suggest that NQC inhibited 5FU-resistant HT29 cells growth through inducing mitotic catastrophe by interference with G2/M cell cycle checkpoint which may open a new avenue for the treatment of 5FU-resistant colon cells.Biography
Je-Wei Tsao is a Research Assistant of Department of Medical Research, China Medical University Hospital, China Medical University, Taiwan. His main research interests are exploring molecular mechanisms of Herbal Medicine and new drugs against cancer development.
Email: Jeweitsao1984@gmail.com
