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The high-molecular fractions from species of two genera (Symphytum and Anchusa) of Boraginaceae family
Symphytum
asperum, S.caucasicum, S.officinale
and
Anchusa italica
were isolated. According to IR, 13C and 1H NMR, 2D
heteronuclear1H/13C HSQC spectral data, the main structural element of these preparations was found to be a regularly
substituted polyoxyethylene, namely poly[3-(3,4-dihydroxyenyl)glyceric acid] (PDPGA) or poly[oxy-1-carboxy-2-(3,4-
dihydroxyphenyl)ethylene]. Such caffeic acid-derived biopolymer to our knowledge has not been knownand has been identified
for the first time. This compound represents a new class of natural polyethers with a residue of 3-(3,4-dihydroxyphenyl)glyceric
acid as the repeating unit. Most of the carboxylic groups of PDPGA from A. italica unlike the polymer of S.asperum, S.caucasicum
and S.officinale are methylated. The 2D DOSY experiment gave the similar diffusion coefficient for the methylated and non-
methylated signals of A. italicaPDPGA. Both sets of signals fell in the same horizontal. This would imply a similar molecular
weight for methylated and non-methylated polymers. S.caucasicumPDPGA inhibited the growth of androgen-dependent and
-independent prostate cancer (PCA) cells both
in vitro
and in vivo. Consistent with
in vitro
results, in vivo study showed that
PDPGA feeding of mice strongly inhibited 22Rv1 tumors growth by 88% at 5 mg/kg body weight doses for 5 weeks, without
any toxicity, together with a strong decrease in androgen receptor and prostate specific antigen expression but increase in
apoptosis in tumor tissues from PDPGA-fed mice. Overall, present study identifies PDPGA as a potent agent against PCA
without any toxicity, and supports its clinical application.
Biography
V Barbakadze completed his PhD and DSciat the ages of 33 and 54 years from ZelinskyInstiute of Organic Chemistry, Moscow, Russia and Durmishidze Institute
of Biochemistry and Biotechnology, Tbilisi, Georgia, respectively. Since 2006 to present, he is the head of laboratory of plant biopolymers at the Tbilisi State
Medical University Institute of Pharmacochemistry. 1996 and 2002 he has been a visiting scientist at Utrecht University (faculty of pharmacy), The Netherlands, by
University Scholarship and The Netherlands organization for scientific research (NWO) Scholarship Scientific Program, respectively. He has published more than
64 papers in reputed journals.
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