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Non communicable risk factors in development of hepatocellular carcinoma among Egyptian chronic liver disease patients
6th Global Gastroenterologists Meeting
Hanaa M Badran, Abdel Rahman El Zayadi, Mostafa H Ragab, Hassan Hamdy and Sally M Emara
Menofya University, Egypt Ain Shams University, Egypt Cairo University, Egypt Abbasia Fever Hosptial, Egypt
Posters & Accepted Abstracts: J Gastrointest Dig Syst
Abstract
The prevalence of hepatocellular carcinoma (HCC) increased tremendously in Egypt over the last decade mainly because of high prevalence of HCV and HBV. The contribution of non communicable risk factors as smoking, pesticides, obesity and diabetes has not been thoroughly assessed. Therefore, we aimed to study the prevalence of the following potential risk factors: smoking, exposure to pesticides, obesity and diabetes among HCC and chronic liver disease Egyptian patients. In the period from January 2003 to December 2008, 595 out of 8550 CLD patients attending CLC were diagnosed as HCC cases and formed group A, while another group B consisted of 1750 CLD patients were taken by random sampling technique. Obesity was calculated by BMI >30 after excluding cases with ascites and edema. The results of the current study revealed that prevalence of HBsAg was nearly the same in both HCC (5.8%) and CLD groups (5.3) (P=0.741) and the prevalence of HCVAb was 90.6% in HCC group versus 82.8% in CLD group (P=0.000). Schistosomiasis was positive in 68.4% in HCC group versus 57.4% in CLD group (P=0.000). The risk of HCC development were increased with increasing age, those in age group 40-59 years were at six folds more risk to develop HCC whereas age 60 years and over were at 16 times more risk (OR=6.1, OR=16.76, P=0.000, respectively). Synergistically with HCVAb and HbsAg positivity, DM, smoking and exposure to pesticides were associated to HCC development (OR=2.7, P=0.000 for obesity, OR=1.6, P=0.000 for DM, OR=1.3, P=0.003 for smoking and OR=1.7, P=0.04 for pesticides exposure), but in absence of HCV and HBV the association increased (obesity OR=10.4, DM OR=1.9, smoking OR=1.4). Exposure to pesticides was only significant for patients in rural regions (OR=10.6, P=0.05). It was concluded that tobacco, obesity, diabetes mellitus were associated with significant increase in risk to develop HCC. This association is pronounced among subjects without evidence of hepatitis virus infection. Exposure to pesticides represents an important health hazard for HCC development in rural CLD patients.Biography
Email: hanabadran21@Hotmail.com
