Journal of Biotechnology & Biomaterials
Open Access

Abstract

Scorpion sting represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world. Inflammatory mediators are thought to be involved in the systemic and local immune response induced by the Tityusserrulatus scorpion envenomation. The aim of this study was to evaluate the effect of extracts of Mimosa tenuifloraon model envenomation. In mice, the envenomation model is induced by Tityusserrulatus venom. Previous treatment of mice with aqueous extracts, fractions and subfractions of M . tenuiflora was able to suppress the cell migration to the peritoneal cavity, not in a dose-dependent manner. The treatment of mice with M. tenuifloraextracts also decreased the level in IL-6, IL-12 and IL-1β. We concluded that administration of the extract, fractions and subfractions resulted in a reduction of cell migration and showed a reduction of level in pro-inflammatory cytokines. This study demonstrates for the first time the antivenom effect of aqueous extract, fractions and subfractions from the Mimosa tenuiflora plant.

Biography

Mariana Angelica Oliveira Bitencourt graduated in Pharmacy from the Federal University of Rio Grande do Norte (2008). Master in Pharmaceutical Sciences UFRN and obtained her doctorate in Development and Technological Innovation in Medicines with experience in immunology and development of new therapeutic for the treatment of poisonings alternatives.