Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 1636
Journal of Gastrointestinal & Digestive System received 1636 citations as per Google Scholar report
Journal of Gastrointestinal & Digestive System peer review process verified at publons
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- China National Knowledge Infrastructure (CNKI)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
Negative brush cytology on endoscopic retrograde cholangiopancreatography (ERCP): Factors associated with malignancy
7th Global Congress on Gastroenterology & Endoscopy
Saif Khan
University of Glasgow, UK
ScientificTracks Abstracts: J Gastrointest Dig Syst
Abstract
Aim: ERCP brush cytology is an established technique for diagnosing pancreato-biliary malignancies. However, its accuracy remains modest with nearly half of malignancies missed. There is a lack of research assessing factors associated with negative brush cytology results. The aim of our study is to analyze factors associated with negative brush cytology samples and their ability to differentiate between malignant and benign samples. Method: Data from all consecutive patients who had ERCP brush cytology in NHS Lanarkshire between January 2006 and December 2015 was retrospectively collected and analyzed. 217 out of 232 patients were included in the final study; their cytology, radiology and ERCP reports were analyzed. Age, ALT, ALP, bilirubin, CEA and CA 19-9 levels along with presence of mass on imaging, mass size, stricture length and location were the factors assessed. Factors highlighted by univariate analysis were further analyzed by binary logistic regression analysis. Results: 138 patients had a malignancy of which 77 had a positive brush cytology sample (sensitivity: 55.8% and specificity: 97.5%). 138 patients had a negative sample and the likelihood of a false negative brush cytology increased with an increase in bilirubin levels {OR 1.005; 95% CI: (1.002-1.008) p=0.001}, ALT levels {OR 1.003; 95% CI: (1.001-1.006) p=0.021} and age {OR 1.045; 95% CI: (1.012-1.079) p=0.01}. Using ROC curves optimal cut-offs for ALT and bilirubin were 84.5 U/L (sensitivity: 70% and specificity: 70%) and 181.5 umol/L (sensitivity: 73% and specificity: 67%). Conclusion: Increasing age, bilirubin and ALT levels are independent predictors of malignancy in a negative brush cytology sample.Biography
Saif Khan has completed his BSc from the University of Bradford and is currently, a 4th year Medical student at the University of Glasgow. He has a keen interest in Gastroenterology and has completed multiple projects in this subject. He has published many papers in reputed journals in collaboration with others. He also has an interest in Imaging and is currently undertaking a project on MRCPs.
Email: 2064724K@student.gla.ac.uk
