Journal of Alzheimers Disease & Parkinsonism
Open Access

Abstract

A treatment to the Alzheimerâ�?�?s disease (AD) consists of inhibition of the Acetylcholinesterase, which is responsible for the acetylcholine control in the synapses. A new class of multi-target-directed ligands (MTDLs) based on a 1,10-phenanthroline5,6-dione derivatives were tested in vitro against acetylcholinesterase (AChE) these compounds inhibit AChE-induced antiamyloid (A�?²) aggregation. 1,10-phenanthroline5,6-dione can act as a lead molecule for developing drug(s) against AD disease with dual functions namely. The in vitro evaluation of the prepared compounds were tested by using Ellmanâ�?�?s colorimetric method in 96-welled microplates some of them showed lower IC50 values on inhibiting the AChE and the IC50 value 6E-6[(2-hydroxyphenyl) imino]-1,10-phenanthrolin-5(6H)-one was 53 mM. This study provided beneficial information for further development of resveratrol derivatives as multitarget-directed agents for AD therapy.

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