Journal of Biotechnology & Biomaterials
Open Access

Abstract

The genus Urginea belongs to family Asparagaceae is found growing in India, Africa, and Mediterranean regions of the world. It is one of the medicinally important genera showing multiple activities to cure various deadly diseases. In the present study anti-inflammatory, anti-diabetic, anti-Alzheimer’s, anti-cancer, anti-oxidant and anti-osteoporosis activity of Urginea species have been discussed. Methanol extract of U. wightii has shown inhibition against raw 264.7 cell lines in lipoxygenase, inhibition assay and exhibited the IC value of 200.7 μg/ml with quercetin as standard. Antioxidant activity was determined by nitric oxide free radical scavenging assay where curcuminoids was used as standard. U. indica and U. wightii showed significant anti-oxidant activity with IC value of 174.1 μg/ml and 371.9 μg/ml respectively. Anti-diabetic activity was detected using alpha amylase inhibition assay with acarbose as standard. Both U. indica and U. wightii have shown significant results with IC value of 253.7 μg/ml and 202.2 μg/ml respectively. Anti-Alzheimer activity was analysed using acetylcholinesterase assay with neostigmine as standard. U. indica showed IC value 121 μg/ ml against standard 0.04 μg/ml. Cell proliferative activity of the extraction on UMR 106 lines against osteoporosis, has revealed. IC50 value of 185.9μg/ml in U. indica and 69.75μg/ml in U. wightii. Anti-cancer activity was determined against cell line MCF-7 using MTT assay. Both the species have showed significant results inhibiting cell growth in MCF-7 cell line and exhibited IC50 value of 325.9μg/ml in U. indica and 424.3μg/ml in U. wightii. These results show Urginea species have a magical potential to heal deadly diseases. Further work is in progress.

Biography

E-mail: mn.shivakameshwari@gmail.com