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Embryo Culture (ECM), Cell, Gamete and Embryo Cryoprotectant (CM), Stem Cell Culture (SCCM), Cell-based Vaccine
Production Media (VPM), etc., contain donor serum proteins (DSPs) which carry risk of disease transmission to patients/
their babies/healthcare workers. The European Union recommends avoidance of non-uniform biologicals in healthcare products
(EU Tissue Directive No.2004/23/EU) by April 2007. Most manufacturers of healthcare products have not fully complied with
this directive. Available embryo culture media (ECM) for human ART supplemented with human serum albumin (HSA)
contain contaminants such as hazardous pathogenic agents, micro DNA/RNA strands and undeclared proteins, all of which
has the potential to cause adverse events for the baby including epigenetic effects, possible genetic crossovers with embryonic
genome affecting the genetic constitution of the embryo and batch variation in quality of media. Late onset adverse events
cannot be ruled out. The author developed synthetic human embryo culture media (Synbiosâ�?¢) devoid of DSPs. A clinical
trial was performed successfully and patented in USA (US Patent 8415094)/PCT protected in Canada, EU, Australia, Russia,
Israel and many nations worldwide. A synthetic spermatozoa cryopreservation medium (SCM) has also been developed and
successfully applied with pregnancies achieved. More efforts are needed to develop culture media for the stem cell and vaccine
industries. Efficacious synthetic ECM and SCM have been developed which eliminates disease transmission, is safe and even
culturally acceptable as it was certified ��?Halal� or permissible by the EU Halal authority. It is anticipated to comply with
regulations.