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Monoclonal antibody and blood plasma abo blood group based therapy against covid-19
4th International Conference and Exhibition on Pharmaceutical Development and Technology
Shimuye Kalayu Yirga
Fujian Medical University, China
ScientificTracks Abstracts: Clin Pharmacol Biopharm
Abstract
In new decade new coronavirus emerged. COVID-19 (SARS-CoV-2) has nucleic acid sequence similarity 96% with bat coronavirus, 79.6% SARS-CoV-1. SARS-CoV-2 and SARS-CoV-1 have common human host-cell ACE2 receptor. This similarity helps for effective vaccine and antibody development. At Wuhan, China, convalescent plasma therapy achieved 70% recovery results. ABO blood group susceptibility study revealed O blood group were very low risk whereas A were at high risk against COVID-19. ABO natural antibodies have positive effect to slowdown COVID-19 in less hygienic environment (less developed) regions. Isolation of specific antibody from EBV transformed B-lymphocyte recovered patients is encouraged. Production of potent neutralizing antibody and vaccine is required. We identified the sensitive immunogenic amino acid segment (318-510) in S1-protein domain that contains important and essential amino acids including cysteine, glutamic acid and aspartic acid, which associated with ACE2 expression. Keywords: Monoclonal antibody, COVID-19, Spiked protein, ACE2, ABO blood groupBiography
Shimuye Kalayu Yirga is an assistant professor from woldia university, Ethiopia. He did Ph.D. in the field of pharmacy. Currently, he is postdoctoral staff at Department of internal medicine (Hematology), Fujian Medical University Union Hospital, China.
