Journal of Biotechnology & Biomaterials
Open Access

Abstract

Lower Urinary Tract Symptoms (LUTS) are the result of bacteria, viruses or undesirable microorganism that invade in to the lower urinary tract and cause infection. LUTS is common in men and although women can get too. In the present study we have taken target proteins for LUTS and cystitis viz. eNOS, PDE5, TRPV1, TRPV4, ERK, NGF, TGF-beta-1 and CDX2 which regulate the functions of smooth muscle cell of lower urinary tract. The target proteins were modeled by different tools for the best 3D - structure prediction. Predicted structures were validated and selected for the docking and virtual screening. The docking and virtual screening was done against the target proteins with Natural compounds and anti-cancer compounds. The anticancer compounds are opted because LUTS can be considered as a preliminary phase of Cancer in lower urinary tract. Out of 5000 natural compounds 2 compounds for eNOS, 2 compounds for PDE5, 2 compounds for TRPV1 and, 1 compound for ERK has been selected. Out of all anticancer compounds Doxorubicin for eNOS, Hydnowightin for PDE5 and TRPV1, and Taxifolin and Apigenin for ERK have been selected.

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