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Molecular characterization of influenza viruses circulating in Cuba April 2009 to August 2010
2nd International Conference on Influenza
Mayra Mune, Alexander Pinon, Amely Arencibia, Belsy Acosta, Odalys Valdes, Susett Oropesa, Guelsys Gonzalez and Rosmery Roque
Pedro Kouri Institute of Tropical Medicine, Cuba
Posters & Accepted Abstracts: J Infect Dis Ther
Abstract
Influenza is a respiratory disease with high epidemic behavior; the main etiologic agents are influenza viruses A and B. The virus influenza A are primarily responsible for annual epidemics and the only causing pandemics. Fighting these viral agents is based mainly in the use of vaccines and drugs that inhibit viral proteins M2 and NA. Currently, the use of antiviral drugs has been limited by the emergency and circulation of influenza virus variants resistant to adamantane worldwide. The neuraminidase inhibitors have been the drug of choice available for the treatment and prophylaxis of influenza virus before the availability of influenza vaccine. The aim of this work was the molecular characterization of influenza virus circulating in Cuba in the period April 2009-August 2010. Phylogenetic analysis of seasonal influenza viruses and pandemic virus showed that both viruses were genetically similar to the strains included in the vaccine recommended by �WHO�. Molecular characterization of these agents circulating in Cuba showed the necessity of systematic monitoring of these Cuban genetic variants. In the present work we identified genetic variants of influenza A resistant to oseltamivir. It was detected for the first time in Cuba the circulation of influenza A (H1N1) viruses with resistant markers to the antiviral drugs available.Biography
Email: mayra@ipk.sld.cu
