Breast Cancer: Current Research
Open Access

Abstract

Background: Among women, the second leading cause of death worldwide is the breast cancer (BC). MicroRNAs (miRNAs) expression participates in breast cancer. Objectives: The purpose of this study is to investigate the expression of miRNA-10b, miR-133a, miR-155 and miR-639 in breast cancer and study their correlation with clinicopathological features and tumor suppressor protein (p53) concentration. Material & Methods: The four miRNAs levels were measured in serum using quantitative real-time PCR (QRT-PCR) and (p53) concentration by enzyme-linked immunosorbent assays (ELISA) in women with breast cancer (n=60) and healthy controls (n=80). Results: In this study miRNA-10b, miRNA-155, and miRNA-639 were overexpressed while miR-133a had down expression in the serum of breast cancer patients compared to control serum. P53 had no significant correlation with any of the studied miRNAs. A significant association was observed between miR-10b and human epidermal growth factor-2 (HER-2) (P=0.046), miR-155 with lymph node involvement (P=0.05), and between miR-133a and tumor grade (P=0.039). Conclusion: These miRNAs have a significant signature in the pathogenesis of breast cancer and can be used as non-invasive molecular biomarkers for breast cancer detection.

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