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In Association with
Microbial involvement in cause and treatment of Alzheimer�s disease
6th World Congress on Biotechnology
Pushpendra Mani Mishra1, Abhishek Shrivastava1, Niraj kumar Jha1, Rashmi K Ambasta1 and Pravir Kumar1,2
1Delhi Technological University, India 2Tufts University School of Medicine, USA
Posters-Accepted Abstracts: J Biotechnol Biomater
Abstract
A complex ecosystem formed by the microorganisms that reside within human organs is gastrointestinal tract, urogenital tract, skin and nasal and oral mucosa. Albeit, largest pool of microbiome in the human body is gastrointestinal tract that comprising 99% anaerobic bacteria and remaining are fungi, protozoan and archaebacteria. The ratio of prokaryotic microbial cells within the human body to eukaryotic human cells is 100:1 and gene ratio is 150:1. Recently, it has been identified that Microbiome resides in human predict four major division of bacterium resides in GI tract namely actinobacteria (3%), bacteroidetes (23%), firmicutes (64%) and proteobacteria (8%). Remainder 2% consists of diverse minor taxonomic division. Further, such kind of microbial cells has been found to involve in the progression of neurodegenerative disorders. Alzheimerâ��s disease is one of the most lethal disorders which befalls several damages in the brain due to accumulation of toxic Amyloid Beta (A�²), directed by mainly dementia, cognitive disabilities and tauopathy. Interestingly, amyloid is secreted by various species of microbiome including bacteria and fungi. Blood examination of AD patients has also revealed through the presence of disperse Mycoses and amyloidogenic fungal protein which was found to link with increased risk of AD due to chronic fungal infection. Molecular mimicry is another factor underlying mechanism for neurodegeneration through bacterial amyloid. In spite of this, many plant and animal viruses are also associated with molecular mimicry and altered protein expression in AD. Based on this ground, we demonstrated the microbial source of amyloid causing AD, illustrated underlying mechanism of AD due to microbial amyloid, elucidated the amyloid protein interaction with other proteins and finally, analyzed the microbial product for AD treatment using in silico techniques.Biography
Email: pushpendramani.mishra@gmail.com Pravir.Kumar@tufts.edu pravirkumar@dce.edu
