Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 2975
Journal of Clinical & Experimental Pathology received 2975 citations as per Google Scholar report
Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- Cosmos IF
- Ulrich's Periodicals Directory
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
- world cat
- journal seek genamics
- j-gate
- esji (eurasian scientific journal index)
Useful Links
Recommended Journals
Related Subjects
Share This Page
Methylation profiles distinguish healthy oral mucosa from lesions
7th World Congress on Molecular Pathology
Nina Milutin Gasperov
Ruder Boskovic Institute, Croatia
ScientificTracks Abstracts: J Clin Exp Pathol
Abstract
Altered DNA methylation is one of the possible factors responsible for different human diseases. The model on which we explore changes in DNA methylation in disease are potentially malignant lesions of the oral mucosa, oral lichen planus (OLP) and oral lichenoid lesions (OLL). These two lesions are difficult to distinguish clinically and histopathologically, while the therapy for them is quite different. Therefore, there is a strong need to find new approach that would easily distinguish OLP from OLL. Epigenetic biomarkers, such as methylated genes could point to changes even before they can be clinically detected. Herein, we will examine the methylation status of some tumor suppressor genes (RARB2) and genes involved in cell cycle regulation, transcription, apoptosis, differentiation and chromosomes repair (CCNA1, C13ORF18, hTERT1, hTERT2, TWIST1). Our previous studies have shown that different methylation of these genes could be a good biomarker of mucosal diseases of the cervix. So, we assumed that these genes could also be changed substantially in the oral mucosa, particularly in the OLP and OLL diagnosis. The OLP and OLL diagnoses are based on clinical examination and confirmed by histopathology. The method of methylation specific polymerase chain reaction (MSP) is used to determine genes promoter methylation status. The methylation profiles will be correlated with different diagnosis of the oral mucosa as well as the healthy controls. Our preliminary results point out that promoter methylation of specific genes differences between normal and probably malignant lesions of the oral mucosa.Biography
Nina Milutin Gasperov has completed her PhD working at the Croatian Academy of Science and Arts and Postdoctoral studies at the Ruder Boskovic Institute, Zagreb, Croatia. She is the Principal Investigator of “Methylation profiles in healthy and ill oral mucosa” project, funded by the European Social Fund. She has published 17 scientific papers in reputed journals and has been Reviewer of one project and in two journals. She has been teaching to postgraduate levels about Dental Medicine, School of Dental Medicine, Croatia.
Email: nmilutin@irb.hr
