Journal of Biotechnology & Biomaterials
Open Access

Abstract

Functional management of fracture non-unions, bone loss associated with trauma, cancer and revision total joint arthroplasty and osteomyelitis remain a significant challenge in the field of orthopaedic surgery. Biomaterials for bone regeneration represent a major attention of orthopedic research. Addition of dopants in biomaterial has appeared as a crucial regulator of bone formation and bone regeneration due to their significant role in the biological processes. Keeping view this in consideration, metallic ion (zinc, strontium, silicon, magnesium, lithium) doped calcium phosphate and glass based scaffold and cements were synthesized in laboratory and after fabricating different porous struts made of these materials and thorough in vitro characterization, these have been used in experimental animal model. Primary bioactivity study of the bare scaffolds was carried out using simulated body fluid (SBF) study. Bone formation over two time points were assessed using fluorescence microscopy, histological analysis, chronological radiology, scanning electron microscopy and micro-computed tomography in rabbit bone defect model. Similarly metallic ion doped brushite cements (BrCs) alone and in combination with insulin like growth factor 1(IGF-1) were also studied in animal bone defect model of same time points. Our findings suggest that addition of dopants alters the physico-mechanical properties of biomaterials and promotes the early stage in vivo osseointegration and bone remodeling that may pave the new insight in bone tissue engineering. Moreover, addition of IGF-1 further improved the performance of cements (BrCs) in terms of bone regeneration in animal model.

Biography

Samit Kumar Nandi, an Associate Professor and Former Head, Department of Veterinary Surgery & Radiology, West Bengal University of Animal and Fishery Sciences, India has completed his PhD from the same University for which he was conferred Jawaharlal Nehru Award by ICAR, Government of India. Further for his contribution to Material Science, he has been awarded the outstanding National Bioscience Award for Career Development 2008, CSIR Technology Award 2010 from Government of India. He has also been conferred Biotech Product and Process Development and Commercialization Award 2013 from his Excellency, President of India. He is a Prolific Writer and has contributed more than 100 scientific articles in national and international journals of repute and is serving as Reviewer of number of journals all over the Globe. He has presented several invited lectures in international conferences in India including China, Singapore, Finland, USA and Thailand.

Email: samitnandi1967@gmail.com