Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

Metabolomics investigation of biological fluids following physical competition may provide useful information in understanding exercises biochemistry. In the present study, we applied metabolomics approach to monitoring the endogenous metabolomic status of volleyball athletes during the competition program and identifying metabolomic variation of athletes with different exercise seniority. Analysis of pre-competition, post-competition and 1-week recovery urine sample by GC-MS and subsequent multivariate statistical analysis revealed alteration in the levels of 16 metabolites in senior group and 21 metabolites in junior group. Separation of post- from pre-competition urine samples in senior group was assigned mainly to phosphate, creatinine, amino acids, and compounds of the Krebs cycle. These metabolites altered in urine with competition suggested the possible malfunction of the kidney caused by the intensive exercise. However, in junior group, the changed metabolites after competition were almost sugars, polyols, organic acids and short-chain fatty acids. These metabolites decreased more with the post-competition compared to the pre-competition, thus indicating that junior players elicited great metabolic disturbances related with energy expenditure, oxidative stress response and gut flora metabolism disorder. Both in senior and junior group, the recovery group were not significantly separated with postcompetition group as a result of the limited time available for recovery. Thus, metabolomics is a useful tool to monitor physical status in volleyball sport during different periods of the competition.

Biography

Wenbin Zhou is in her second year of PhD in Shanghai University of Traditional Chinese Medicine, China. Her major reseach is about Metabolomics. She has published one paper in Journal of Chromatography B.

Email: zhouwenbin41@163.com