Journal of Biotechnology & Biomaterials
Open Access

Abstract

Eugenol is one of the important chemical constituent of the essential oils of many aromatic plants, such as Eugenia caryophyllus, Dicipelium cariophyllatum, Pimenta dioica, Croton zehntneri, and Ocimum species. Recent studies suggest that Ocimum (tulsi) may be a COX-2 inhibitor, like many modern painkillers, due to its high concentration of eugenol (1-hydroxy-2-methoxy-4- allylbenzene). Ocimum is proven to be an effective treatment for diabetes by reducing blood glucose levels. Previous study showed that high glucose level in blood results in the increase transcription of Cyclooxgenase-2 (Ref:Narkunraja Shanmagum,Irene T. Gaw Ganzalo and Rama Natarajan). The basic idea behind the work is to reverse this process and for that Eugenol synthase comes in picture. Eugenol synthase suppresses COX 2 expression that has already been proved by Sun Suk Kim et al. There are around 410 experimentally proven medicinal plants having Anti-diabetic properties but the complete mechanism of action is available only for about 109. There are several medicinal plants whose extract modulate glycolysis, Krebs cycle, gluconeogenesis, HMP shunt pathway, glycogen synthesis and their degradation, cholesterol synthesis, metabolism and absorption of carbohydrates, and synthesis and release of insulin. This work provides a comprehensive overview of Meta Analysis of Eugenol Synthase-I in Ocimum basilicum.

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