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Meningioma 1 (MN1) expression: Refined risk stratification in acute myeloid leukemia with normal cytogenetics (CN-AML)
9th World Digital Pathology & Pathologists Congress
Lamiaa Ibrahim
Mansoura Medical School, Egypt
Posters & Accepted Abstracts: J Clin Exp Pathol
Abstract
Background: Prognostic stratification of cytogenetic normal acute myeloid leukemia (CN-AML) is an area of active research. Aim: The aim of this study was to determine the prognostic importance of the meningioma 1 (MN1) gene expression levels in CN-AML. Methods: One hundred patients with CN-AML were diagnosed and MN1 expressions were analyzed using quantitative real-time polymerase chain reaction. Results: High expressions were detected in 48 (48%) patients (expression range: 2.35â�?�?31.99, mean: 13.9�?±8.49) in comparison with 52 (52%) patients with low expression (expression range: 0.02â�?�?2.3, mean: 0.68�?±0.77). The course of the disease in patients with high MN1 expression was unfavorable. Patients with high MN1 expression was associated with significant low complete remission rate (62.5 vs. 8.4%, high vs. low MN1, P=0.001) and high mortality rate (75% vs. 46.1, P=0.03). AML patients with high MN1 expression tended to be refractory (37.5 vs. 19.2%, P=0.00) and relapse risk (54.1 vs. 23%, P=0.02). Multivariable analysis confirmed high MN1 expression as an independent risk factor for disease-free survival and overall survival. Conclusion: MN1 over expression independently predicts bad clinical outcome in CN-AML patients.Biography
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