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lncRNA expression signatures in response to tiaozhi jiangtang formula in type 2 diabetes mellitus (T2DM) with obesity and hyperlipidemia
International Conference on Childhood Obesity & Child Development
Lisha He, Linhua Zhao, Han Wang and Xiaolin Tong
Guang�anmen Hospital, China Academy of Chinese Medical Sciences, China
Posters & Accepted Abstracts: J Obes Weight Loss Ther
Abstract
Metabolic syndrome represents a group of complex metabolic diseases, which is characterized by obesity, combined with impaired glucose levels, hypertension and hyperlipidemia. Traditional Chinese medicine has rich experience in solving this series of problems through an overall adjustment via multi ways and targets, but the exact molecular mechanisms are unclear. Long non-coding RNAs (lncRNAs) represent a subgroup of non-coding RNAs that are longer than 200 nucleotides. Notably, the deregulation of lncRNAs has also been shown to result in aberrant gene expression that contributes to the progression of metabolic syndrome treatment. Previous studies conducted by our research team have confirmed the effectiveness of TCM prescription tiaozhi jiangtang on reducing body weight, blood sugar and blood lipids. In this study, patients with type 2 diabetes, obesity and hyperlipidemia were treated by traditional Chinese medicine tiaozhi jiangtang prescription of 24 weeks; we chose 6 effective cases and 6 invalid cases as control to analyze the molecular mechanism of TCM treatment. According to the research of LncRNA microarray, GO analysis, Pathway analysis and qPCR validation and it was found that the target LncRNAs LDHA, XLOC_011623, as well as their associated mRNAs LDHA, ATP6V0C contribute to the good outcome of tiaozhi jiangtang formula.Biography
Lisha He is currently pursuing her PhD from China Academy of Chinese Medical Sciences and Doctoral studies from Beijing University of Chinese Medicine. She has published more than 15 papers both in national and international reputed journals.
Email: jqhelisha@163.com
