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Involvement of oxidative stress and nitric oxide in fibromyalgia pathophysiology, a relationship to be elucidated
International Conference on Fibromyalgia and Chronic Pain
Andrei Pereira Pernambuco, Luana Pereira Leite, Luciana de Souza Cota Carvalho and D�©bora dAvila Reis
Universidade Federal de Minas Gerais, Brazil Centro Universit�¡rio de Formiga, Brazil Universidade de Ita�ºna, Brazil Universidade Federal do Vale do Jequitinhonha e Mucuri, Brazil Hospital Mater Dei, Brasil
Posters & Accepted Abstracts: J Pain Relief
Abstract
Fibromyalgia (FM) is a rheumatologic syndrome characterized by chronic pain associated to others signs and symptoms, such as, sleep disturbances, fatigue, depression, anxiety and others. The pathophysiology is not completely elucidated. Genetic, neuroendocrine, immune and behavioral alterations seem to contribute to its genesis and evolution. Recently some studies have proposed the involvement of oxidative stress and nitric oxide but the mechanism is not clear. Probably this process has begun with a disturbance in the balance of reactive oxygen species (ROS) and antioxidants. The accumulation of ROS, attack the polyunsaturated fatty acids in the cell membrane causing the lipid peroxidation which cause damage to the cell membrane with its rupture and release of contents. The main goal of this review is to gather and organize the available literature about the role of oxidative stress and nitric oxide in the FM symptoms.Biography
Email: pernambucoap@ymail.com
