Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 1437
Journal of Clinical & Experimental Pathology received 1437 citations as per Google Scholar report
Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- Cosmos IF
- Ulrich's Periodicals Directory
- RefSeek
- Directory of Research Journal Indexing (DRJI)
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
- world cat
- journal seek genamics
- j-gate
- esji (eurasian scientific journal index)
Useful Links
Recommended Journals
Related Subjects
Share This Page
Investigation for polymorphisms of caspase 3 and caspase 9 gene and enzyme levels in leukemia patients
13th International conference on Pathology and Molecular Diagnosis
Melek Meydanogullar�±, Nazan Eras, Naci Tiftik, Anil Tombak and Etem Akbas
Mersin University, Turkey
ScientificTracks Abstracts: J Clin Exp Pathol
Abstract
For understanding of leukemia and its treatment with early diagnosis, the molecular changes that occur during the development of leukemia should be investigated. Apoptosis is central to the development and homeostasis of the hematopoietic system. Previous studies have reported that leukemia cells invariably have abnormalities in one or more apoptotic pathways. The current study investigated the relationship between polymorphisms of caspase 3 G>T rs4647601 and caspase 9 A>G rs4645978 and leukemia. Besides that, we aimed to determine caspase 3 and caspase 9 enzyme levels possible effects on the risk of developing leukemia. The case group consisted of 100 patients (mean age: 56�±03) who had been newly diagnosed with leukemia at the Department of Hematology, Mersin University Faculty of Medicine, Turkey. The control group comprised of 100 healthy properly age and sex matched individuals (mean age: 54�±15) with a no history of leukemia. The genotypes were detected by using Real-Time PCR. We measured enzyme levels of caspase 3 and 9 in serum, which were obtained from blood samples. No significant association was observed between caspase 3 G>T rs4647601 and caspase 9 A>G rs4645978 polymorphisms and leukemia. We found that median levels of caspase 3 and 9 were higher in leukemias than in normal blood cells (P<0.001). This is the first study reporting the detailed distribution of alleles and genotypes of caspase 3 and caspase 9 in leukemia patients in Turkish population. Taken together, we conclude that caspase 3 and caspase 9 levels may be useful for the early diagnosis of leukemia.Biography
Nazan Eras, after graduation from Dicle University Faculty of Medicine, worked as a General Practitioner. She completed her MSc in 2006 and PhD in 2012 at Mersin University Faculty of Medicine, Department of Molecular Biology and Genetics. She has been serving as Peer-reviewer in journals. She still continues to work as a Scientist and an Assistant Professor at Mersin University Medical Faculty, Department of Medical Genetics. Her research interests include Clinical Cancer Genetics, Human Molecular Genetics and Oxidative Stress.
Email: nazaneras@gmail.com
