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Investigating miRNA-661 and ATG4b mRNA expression as potential biomarkers for hepatocellular carcinoma
Joint Event on 15th World Congress on Biotechnology And Biotech Industries Meet and 2nd International Conference on Enzymology and Molecular Biology
Osama Saber, Mahmoud A Ali, Marwa Matboli, Nashwa El-Khazragy, Nourhan Hossam, Ahmed Hamdy, Sarah El-Nakeep, Ayman El-Sayed Shafei and Randa Mostafa
Armed Forces College of Medicine, Egypt Ain Shams University, Egypt
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Aim: In this study, we aimed to examine the statistical association of serum expression of miR-661 and ATG-4b mRNA with HCC based on in silico data analysis followed by clinical validation. Patients & Methods: Bioinformatics prediction was first applied to retrieve the potential miR serving as an epigenetic regulator of ATG-4b mRNA. Real-time quantitative polymerase chain reaction( RT-qPCR) were used to examine the expression of miR-661 and candidate target gene ATG-4b mRNA in 105 hepatocellular carcinoma (HCC) patients, 50 chronic hepatitis C infected ( CHC) patients and 45 healthy controls. The prognostic efficacy of the chosen genes was also explored. Results: The expression of miR-661 and ATG-4B mRNA was positive in 97.14% and 77.14%, respectively. HCC patients with strong discriminating power between HCC and control showed AUC=0.9 and 0.8, respectively. The median follow up period was 28 months. The survival analysis showed that ATG-4b mRNA was not dependent on the prognostic factors. We also found that miR-661 was positively correlated with ATG-4b mRNA in patients 'sera samples. Conclusion: This is the first report about the considerable clinical use of miR-661 and ATG-4b mRNA in early detection and followup of HCC patients.Biography
Osama Saber is a second year Medical Cadet in Armed Forces College of Medicine (AFCM). He is a member of International Genetic Engineering Machine Foundation. He has published many papers in various reputed journals.
Email: habiba20062001@yahoo.com
