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Investigating miRNA-661 and ATG4b mRNA expression as a potential biomarkers for hepatocellular carcinoma
12th International Conference on Pediatric Pathology & Laboratory Medicine
Osama Saber, Mahmoud A Ali, Marwa Matboli, Nashwa El-Khazragy, Nourhan Hossam, Ahmed Hamdy, Sarah El-Nakeep, Ayman El-Sayed Shafei1 and Randa Mostafa
Armed Forces College of Medicine, Egypt Ain Shams University, Egypt
Posters & Accepted Abstracts: J Clin Exp Pathol
Abstract
Aim: We aimed to examine the statistical association of serum expression of miR-661 and ATG-4b mRNA with HCC based on in silico data analysis followed by clinical validation. Patients & Method: Bioinformatics prediction was first applied to retrieve the potential miR serving as an epigenetic regulator of ATG-4b mRNA. Real-time quantitative polymerase chain reaction (RT-qPCR) were used to examine the expression of miR-661 and candidate target gene ATG-4b mRNA in 105 hepatocellular carcinoma (HCC) patients, 50 chronic hepatitis C infection (CHC) patients and 45 healthy controls. The prognostic efficacy of the chosen genes was also explored. Results: The expression of miR-661 and ATG-4B mRNA was positive in 97.14% and 77.14%, respectively, HCC patients with strong discriminating power between HCC and control (AUC=0.9 and 0.8, respectively). The median follow up period was 28 months. The survival analysis showed that both ATG-4b mRNA and miR-661 were independent prognostic factors. Of note, we found that miR- 661 was positively correlated with ATG-4b mRNA in patients� sera samples. Conclusion: This is the first report about the considerable clinical use of miR-661 and ATG-4b mRNA in early detection and follows up of HCC patients.Biography
Email: habiba20062001@yahoo.com
