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Integrated multiregional analysis proposing a new model of colorectal cancer evolution
9th World Digital Pathology & Pathologists Congress
Koshi Mimori
Kyushu University Beppu Hospital, Japan
Posters & Accepted Abstracts: J Clin Exp Pathol
Abstract
Cancer is heterogeneous disease; each tumor in different patients has different cancer genomes. Furthermore, another level of heterogeneity exists: Even a single tumor harbors multiple genetically distinct subclones. This intratumor heterogeneity is presumably one of causes of therapeutic difficulty and its understanding is clinically necessary. In this study, we investigated intratumor heterogeneity in colorectal cancer by analyzing sample obtained from geographically separated regions of 9 colorectal tumors. Our integrated data analyses combined with computational simulation strongly suggest that, after clonally shared alterations were accumulated by aging; numerous subclones were generated by neutral evolution. Importantly, this view can explain the robustness and evolvability of cancer: Therapeutic action inducing an environmental change would convert some of the numerous neutral mutations to driver genes that confer therapeutic resistance. We believe that this study not only provides insights into colorectal cancer pathogenesis but also constitutes a new basis for designing therapeutic strategies.Biography
Email: pa19107@me.com
