Journal of Biotechnology & Biomaterials
Open Access

Abstract

Oxygen is requisite in biological systems to converge their energy demands and supply of nutrients in our body. The generation of free radicals is the most common consequence of oxygen consumption which may lead to the damaging of cells. Importantly, antioxidant system of the body has a pertinent role in prevention of any loss that arises due to the generation of free radicals. However, dysfunction of antioxidant system or due to overproduction of free radicals may lead to some serious consequences which affect normal brain functionality. The brain tissue is greatly prone to the effects of reactive oxygen species due to its high demand for oxygen. Apart from several other environmental factors, oxidative stress (OS) plays a critical role in free-radical attack on neural cells leads to the loss of function that eventually contributes to neurodegeneration. However, antioxidants have defensive role against such kind of oxidative stress to prevent neuronal damage. Antioxidants may also be used as a therapeutic agent against intense neuronal loss, as they have the ability to neutralize free-radicals. Diet is a chief source of antioxidants, as well as medicinal herbs are also found to be a commercial source of antioxidants at present. Currently, we have focused on the natural compounds with good antioxidant and anti-inflammatory property that elicit neuroprotection. Herein, using different in silico techniques, we have validated the potential protective role of Cannabinoids in neurodegeneration. Furthermore, in silico techniques encompass string database for protein-protein interaction and docking for finding proper interaction between drugs and protein molecules have been identified.

Biography

Email: abhi05chitransh@gmail.com Pravir.Kumar@tufts.edu pravirkumar@dce.edu