Breast Cancer: Current Research
Open Access

Abstract

Breast cancer has been defined as the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012. We did p53 protein expression study through immunohistochemistry in 105 cases breast cancer cases from India. The study was attempted to improve the prognostic and predictive value of p53 in breast cancer. Prior informed consent and ethical approval was obtained form Rajiv Gandhi Cancer Hospital and Research Centre, New Delhi, India. All patients and normal controls were subjected immunohistochemistry using p53 gene antibody to check the expression level of p53 protein in paraffin embedded tissue slides of 4mm thickness. All non-neoplastic cases showed no expression for p53. In the tumor samples, immunohistochemical scoring was done as low or no expression (+), moderate expression (++) and high expression (+++). So, out of 105 cases studied, 26 cases (26/105, 24.80%) had low (+) or no expression of p53 protein, 50 cases (50/105, 47.60%) had moderate (++) expression and 29 cases (29/105, 27.60%) had high (+++) expression of p53 protein. In our study sample, we were not able to find any significant association between p53 gene expression and the clinico pathological variables like age, nodal status, tumor stage, menopausal status, ER status, HER 2 status and histological grade. Our study did provide the information on the evaluation of p53 significance in cancer cases from India and larger population based study will be needed to show the presence or absence of the biomarker property of p53 in breast cancer.

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