ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Google Scholar citation report
Citations : 2975

Journal of Clinical & Experimental Pathology received 2975 citations as per Google Scholar report

Journal of Clinical & Experimental Pathology peer review process verified at publons
Indexed In
  • Index Copernicus
  • Google Scholar
  • Sherpa Romeo
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Cosmos IF
  • Ulrich's Periodicals Directory
  • RefSeek
  • Directory of Research Journal Indexing (DRJI)
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • ICMJE
  • world cat
  • journal seek genamics
  • j-gate
  • esji (eurasian scientific journal index)
Share This Page

Immunoexpression of progesterone receptor, epithelial growth factor receptor and galectin-3 in uterine smooth muscle tumors

13th European Pathology Congress

Mervat M Soltan, Abdelkader M Albasr1, Maha K Eldosoukyand Hanan S Abdelhamid

Taibah University, KSA National Liver Institute, Egypt Alminia University, Egypt Cairo University, Egypt

Posters & Accepted Abstracts: J Clin Exp Pathol

DOI: 10.4172/2161-0681-C1-038

Abstract
Background: Uterine smooth muscle tumors constitute a spectrum of neoplasms. Usually diagnosis of leiomyomas (LMs) is straight forwards; however, atypical leiomyomas (ALMs), and smooth muscle tumors of uncertain malignant potential (STUMPs) have overlapping features and need to be distinguished from leiomyosarcoma. Aim: Aim of this study is to evaluate progesterone receptor (PR), epithelial growth factor receptor (EGF-R) and galectin-3 expression in LMs, ALMs, STUMPs, and leiomyosarcoma and to assess their possible role in differentiating those tumors. Materials & Method: Immunoexpression of EGF-R, PR and galectin-3 were studied in 44 cases of uterine smooth muscle tumors. Tissue samples from 20 LMs, 9 ALMs, 5 STUMP and 10 leiomyosarcoma cases were studied. Semi-quantitative score was used to evaluate immunohistochemical staining. Results: EGF-R overexpression was detected in leiomyosarcoma compared to lack of or reduced EGF-R expression in the non-sarcomatous group (LMs, ALMs and STUMPs) with a highly significant difference (p<0.001). On the contrary, there was weak or negative PR staining in leiomyosarcoma as compared to intense PR expression in the non-sarcomatous group with a highly significant difference (p<0.001). Regarding galectin-3, it was down-regulated in leiomyosarcoma compared to the nonsarcomatous group with a significant difference (p<0.01). Correlation analysis revealed negative correlation between EGF-R and PR expression with significant statistical results. While correlation of galectin-3 with EGF-R and PR showed insignificant statistical results. Conclusion: Immunoexpression of EGF-R, PR and galectin-3 could help in differentiating challenging cases of uterine smooth muscle tumors. Further studies are recommended to investigate interactions between EGF-R, PR and galectin-3 and to plan new therapeutic strategies.
Biography

Maha K Eldosouky is a pathologist in Faculty of Medicine at the Taibah University, KSA, Egypt and she is working at the Department of Anatomy, Faculty of Medicine, Alminia University, Egypt. She is having more than 10 publications in reputed journals.
 

Top