Journal of Biotechnology & Biomaterials
Open Access

Abstract

Metal Organic Frameworks (MOF) and their derived compounds have become an important area of research in materials chemistry. Due to enormous advantages of MOFs, researchers are exploiting them for a number of technological applications such as in sensing, gas storage, separations, catalysis, luminescence, etc. The coordination geometry of the metal and the topology of the linkers in the MOFs provide strong chemical bonds and ordered structure to these compounds, thus imparting high thermal and chemical stability. Post synthetic modification further imparts additional properties that can be exploited in applications such as bio-sensing, imaging, drug delivery etc. In the present work, Cu-MOF films have been grown on alumina substrate as a robust bio-sensing platform using solvothermal technique at room temperature. The topological studies of as-grown films were carried out using field emission scanning electron microscope (FE-SEM) and Atomic Force Microscopy (AFM). The synthesized MOF was characterized using UV-Vis spectroscopy, FTIR, XRD and FE-SEM. The conductivity to the synthesized MOF films was introduced by immersing in TCNQ/chloroform solution for 72 hours. Anti-BSA antibodies have been conjugated to the pendent groups of MOF film using EDC-NHS chemistry. The developed biosensor can be explored further for the conductometric sensing of counter antigen i.e., BSA protein by measuring change in conductivity of MOF film for development of specific and sensitive sensors for bio-sensing applications.

Biography

Atal Anudeep Singh Gill is currently a student at Amity University (Noida). He is pursuing his BTech+MTech (dual) Nanotechnology degree. His research interests are MEMs, NEMs, Bio-electronic nanosensors, solar cells and fuel cells.

Email: dr.akashdeep@gmail.com