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Identifying neuropsychological profiles associated with white matter hyperintensities
3rd International Conference on Alzheimers Disease & Dementia
Jana Kynast, Leonie Lampe, Tobias Luck, Katrin Arelin, Dominik Fritzsch, Karl-Titus Hoffmann, Steffi G Riedel-Heller, Arno Villringer and Matthias L Schroeter
Max Planck Institute for Human Cognitive and Brain Sciences, Germany
Background: White matter hyperintensities (WMH) feature as a marker of long-term white matter (WM) degeneration, caused
by a broad range of pathologies. WMH can be detected on T2-weighted fluid attenuated inversion recovery (FLAIR) magnetic
resonance imaging (MRI) scans and progressively increase with age. Age-related WMH are strongly associated with vascular
risk factors and are assumed to cause a global decline in cognitive performance. The progression of WMH majorly affects
attention and executive functioning. However, a comprehensive, domain-specific characterization of the neuropsychological
features associated with WMH is needed to validate recent findings and to further identify cognitive patterns associated with
WMH.
Aim: Here, we aim at the identification of neuropsychological characteristics associated with WMH in a large, non-clinical
sample.
Methods: We included 850 persons participating in the study of the Leipzig Research Centre for Civilization Diseases at the
University of Leipzig, Germany (M = 60 years, SD = 13.1 years, range: 21-79 years). MRI was acquired for every participant with
a 3 Tesla MRI-scanner. The amount of WMH on the individual FLAIR sequences was quantified on the 4-stage Fazekas scale
(Fazekas, 1987) by experienced neuroradiologists. The sample was categorized in 4 Fazekas groups. Age, sex and education
were identified as confounding factors.
The neuropsychological test battery included the Trail Making Test (parts A and B), the Stroop Test, the Consortium to
Establish a Registry of Alzheimer�?¢�?�?�?�?s Disease (CERAD) test battery and the 20-item Dysexecutive Questionnaire (DEX) of the
Behavioral Assessment of the Dysexecutive Syndrome (BADS). Neuropsychological subtests were assigned to the cognitive
domains attention, executive function, memory, learning, language, verbal fluency and perceptual-motor abilities, under wellestablished
theoretical considerations and with respect to the clinical diagnostic criteria for mild and major neurocognitive
disorder.
Individual test results were age-standardized (M = 0, SD = 1) to the mean of the corresponding age group (<65 y, 66-69
y, 70-74 y, 75+ y). Age-standardized scores corresponding to the same cognitive domain were averaged to seven cognitive
domain scores indicative of objective cognitive performance. A content based categorization of DEX items to five cognitive
domains (attention, executive function, memory, language and social cognition) was applied. The sum score for every domain
was age-standardized to the mean of the corresponding age group. Differences between the four Fazekas groups in (1) objective
cognitive performance (7 measures) and (2) subjective cognitive complaint (5 measures) were analyzed with the nonparametric
rank-sum test with data-alignment (critical alpha level: p < .05. Data was aligned for the effects of sex and education and their
interaction with Fazekas score. Data was corrected for identical ranks. Group differences were examined using the single
comparison algorithm proposed by Schaich&Hamerle. For single comparisons, the alpha level was adjusted due to multiple
comparisons.
Results: A general decline in cognitive performance is associated with a higher Fazekas score. The decline in cognition becomes
evident with higher lesion load (starting at Fazekas score 2). Fazekas groups significantly differed in performance measures
of attention (IA�?²(3,846) = 13.77, p < .01) and executive functions (IA�?²(3,846) = 12.84, p < .01). Analyses yielded marginally
significant group differences in objective measures of memory (IA�?²(3,438) = 7.74, p = .05) and visuo constructi veabilities
(IA�?²(3,434) = 7.73, p = .05). In all four cognitive domains, performance significantly declines with larger WM lesion load
(Fazkasscore 2), while low lesion load (Fazekas score 1) was not associated with a decline in cognitive performance.
Fazekas groups significantly differed in measures of memory complaint (IA�?²(3,796) = 18.8, p < .001) and complaint on executive
function (IA�?²(3,796) = 39.88, p < .001). For both measures, persons with low lesion load (Fazekas score 1) worried significantly
less than healthy persons (Fazekas 0) and persons with larger lesion load (Fazekas score 2, 3).Conclusion: Results show a substantial decline in cognitive performance with larger lesion load, which becomes evident at
progressed stages of WMH (starting from Fazekas score 2). In line with recent literature, attention and executive function are
assumed to be major dimension of cognitive decline. Furthermore, results suggest that small, punctual lesions (Fazekasscore
1) are less likely to be associated with impaired cognitive performance. A similar relation has also been found for subjective
cognitive performance. Memory and executive functions are majorly affected by WMH and correspond to the results of
objective cognitive performance. Surprisingly, persons with small WM lesions tend to be less worried about their cognitive
performance than healthy persons. However, larger lesion load (Fazekas score 2 & 3) was associated with increased subjective
complaint. This large cohort study contributes to the framework of age related WM changes and their association with domain
specific cognitive performance and subjective cognitive complaints.
Biography
Jana Kynast has completed her BA and MA in Psychology at the age of 25 years from the University Of Leipzig, Germany. In 2014 she became a fellow of the International Max Planck Research Network on Aging and started her PhD at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig. Her research interests are the neuropsychology of mild cognitive impairment and dementia as well as its relation to neuroimaging and genetic biomarkers of dementia and dementia