Journal of Biotechnology & Biomaterials
Open Access

Abstract

Oral lichen planus (OLP) is a chronic infl ammatory mucocutaneous disease. Th e cause of lichen planus is not known. Oral lichen planus aff ects women more than men (1.4:1). Oral lichen planus occurs predominantly in adults over 40, although younger adults and children may be aff ected. Th e purpose of this study is to determine relationship between HLA-DR and DQ antigen and oral lichen planus disease. Whole blood sample of Oral lichen planus patient were subjected to study the HLA-DR and DQ, with PCR-SOP method. Oral lichen planus patients were selected for HLADR and DQ typing with PCR method.56 patients (42 woman and 14 men) tested. A strong association was found between HLA-DR3 and OLP. But there was not relationship betweenHLA-DQand OLP disease. Fift y six OLP patients (42 woman and 14 men) were subjected to conventional PCR-SOP for HLA-DR and DQ typing (Innotrain, Germany). Predominant HLA- DR were HLA -DR3 (61.2%). But there was not relationship between HLA DQ and OLPdisease. HLA-DR3 is signifi cantly higher in oral lichen planus patient.

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