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In Association with
Highly efficient bio-functionalized nanostructured hafnia based non-invasive biosensor for oral cancer detection
6th World Congress on Biotechnology
Suveen Kumar, Saurabh Kumar, Shine Augustine and Bansi D Malhotra
Delhi Technological University, India
Posters-Accepted Abstracts: J Biotechnol Biomater
Abstract
We report results of the studies relating to the fabrication of novel nanostructured immunosensor platform (BSA/anti- CYFRA-21-1/APTES/HfO2/ITO) for efficient detection of oral cancer biomarker (CYFRA-21-1) in saliva. Nanostructured hafnia has been synthesized via low temperature hydrothermal process and surface modified with 3-aminopropyltriethoxy silane (APTES) for covalent immobilization of monoclonal anti-CYFRA-21-1. The fabricated platform has been characterized using atomic force microscopy (AFM), photo-electron spectroscopy (XPS), FT-IR and electrochemical techniques. The results of the electrochemical response studies reveal that the BSA/anti-CYFRA-21-1/APTES/HfO2/ITO immunoelectrode can be used to estimate the CYFRA-21-1 with high sensitivity (9.2 mA mL ng-1 cm-2) and wide linear detection range (LDR) of 2 to 18 ng mL-1. The limit of detection (LOD) obtained as 0.143 ng mL-1 and shelf life of 7 weeks indicates that this stable immunoelectrode can be efficiently be used in the detection of concentration of protenaceous CYFRA-21-1 antigen in saliva samples. The observed results validated using ELISA reveal that this biosensor can be used as a point-of-care device for oral cancer monitoring.Biography
Email: suveendev@gmail.com
