Toxicology: Open Access
Open Access

Abstract

To investigate the mode of action of Phyllanthus niruri as a prophylactic hepato-protective agent against Paracetamol (PCM) induced liver toxicity in albino rats. Five groups of six animals in each group of Wistar rats with a weight of 180-210 gm were the experimental material. Group-I was served as normal control, administered sodium CMC for all the eight days. Group-II rats were treated only with PCM at a dose of 2.5 gm/kg on 8th day. Group-III animals were administered silymarin at a dose of 50 mg/kg for eight days and PCM at a dose of 2.5 gm/kg on 8th day, while Group-IV is the treated group which was given P. niruri aqueous extract at a dose of 200 mg/kg followed by PCM of 2.5 gm/kg on 8th day. Group-V rats were administered with P. niruri at a dose of 400 mg/kg for 8 days and PCM at a dose of 2.5 gm/kg on 8th day. Biochemical, histological and immunehistological (IHC) examinations were performed. Histo-pathological picture is in line with the biochemical parameters and IHC study revealed that P. niruri acts by preventing the increase in NKT cells subsequently blocking FASL, by anti-apoptotic and by increasing regeneration. Phyllanthus niruri aqueous extract at a dose of 400 mg/kg was more effective than at 200 mg and silymarin 100 mg.

Biography

Akshath S U is currently pursuing his MBBS from Saveetha Medical College, SIMATS. His research is on the hepato-protective effect of Phyllanthus niruri against the Paracetamol induced liver toxicity in albino rats under the mentorship of Dr. Sankaran, Department of Anatomy, SIMATS in India.
Email:akshath.s.u@gmail.com