Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

The objective of this study was to examine the relationship between adherence and HRQoL in resistant and pseudoresistan hypertensive patients.We conducted a cross-sectional study with hypertensive outpatients. Hypertensive patients were divided into three groups: patients with controlled hypertension, patients with Resistant Hypertension (RHTN) and patients with pseudoresistant hypertension (pRHTN). Adherence was assessed using a validated version in Portuguese of the 8-item Morisky Medication Adherence Scale (MMAS- 8). Patient HRQoL was assessed using SF-36 survey. 183 patients were included in the study; mean age was 55.1 years (SD 11.08) and 66.8% were female. Only 94 (51.4%) patients achieved BP control, 20 (10,5%) met criteria for RHTN and 97 (53.0%) were pseudoresistant hypertensive patients. Systolic blood pressure was significantly higher (p <0.00) among patients with the pseudoresistant hypertension. As expected, patients with RHTN showed lower scores for physical functioning (P = 0.04), vitality (p = 0.035) and mental health (p = 0.028), however, the subgroup of patients with pseudoresistant hypertension due to poor medication adherence showed the worst scores in all domains of HRQoL (p = 0000). The non-adherent behavior besides being an important cause of pseudoresistant hypertension appears to be linked to reduced HRQoL and difficulty controlling blood pressure. The identification of such cause and contribute to the diagnosis of pseudoresistant hypertension ,as enables the adoption of measures to improve the quality of life, especially those that promote self-care, targeting the needs of these patients.

Biography

Sabrina Joany Felizardo Neves has completed his PhD at from Federal University of Pernambuco. She is the coordinator of pharmacy course of Federal University of Alagoas. Conducts research in the area of clinical pharmacy and pharmacoepidemiology. She has published papers in reputed journals.