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Haematological studies of streptozotocin-induced diabetic rats treated with extract of Momordica Charantia
3rd International Conference and Exhibition on Obesity & Weight Management
Omobola A Komolafe2,3, David A Ofusori2,3, Olarinde S Adewole3 and Jegede A Isaac1,2
1Ladoke Akintola University of Technology, Nigeria 2University of KwaZulu-Natal, South Africa 3Obafemi Awolowo University, Nigeria
Posters: J Obes Weight Loss Ther
Abstract
The present study investigated the effects of M. charantia on haematological changes of streptozotocin-induced diabetic Wistar rats. Forty healthy adult Wistar rats of both sexes were randomly assigned into five groups A, B, C, D and E of eight rats each. Group A were the control (normal rats); B were the experimentally-induced diabetic rats; C were diabetic rats treated with methanolic extracts of M. charantia for two weeks (withdrawal group); D were diabetic rats treated with methanolic extracts of M. charantia for four weeks. E was diabetic rats treated glimepiride for four weeks. Blood samples obtained by cardiac puncture were used for haematological studies. Results showed significant (p<0.05) increase in most RBC indices in groups D and E. Reduced WBC and NEUT count in diabetic group was significantly (p<0.05) increased in groups D and E. Lymphocyte count was not significantly affected. Platelet count, PDW and MPV were significantly (p<0.05) reduced in groups D and E following an increase in diabetic group. Thus M. charantia could restore some haematological changes in diabetic animals, and in a manner similar to glimepiride.Biography
Ayoola Isaac Jegede has received his Masters in Anatomy at University of Lagos, Lagos, Nigeria and currently doctoral student in the Discipline of Clinical Anatomy, School of Laboratory Medicine & Medical Sciences, College of Health Sciences, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. He is a lecturer at the department of Anatomy, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria; where he has being actively teaching in the last fifteen years. His research has included Diabetes Mellitus, Male Reproductive Biology and Endocrinology, and recently Testicular Stereology Status of Hypertensive State in AIDs/ HIV. He has authored a reasonable number of research articles in reputable international journals to his credit. He is a member Anatomical Society of Nigeria, Morphology and Andrology Research Group, DOCA UKZN, Diabetes Research LAUTECH.
Email: ayoolajegede@yahoo.co.uk
