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Graphene oxide and gold nanorods conjugates for controlled release of doxorubicin by using 808 nm laser
International Conference and Expo on Biopharmaceutics
M Shahnawaz Khan1, Sunil Pandey3, Mukesh Lavkush Bhaisare3, Mukeshchand Thakur1 and Hui-Fen Wu1, 2, 3
1National Sun Yat-Sen University and Academia Sinica, Taiwan 2Kaohsiung Medical University, Taiwan 3National Sun Yat-Sen University, Taiwan
ScientificTracks Abstracts: Clin Pharmacol Biopharm
Abstract
Graphene Oxide (GO), a close derivative of graphene has unlocked many pivotal steps in drug delivery due to their inherent biocompatibility, heavy drug loading capacity and high aqueous solubility. We used a novel plant material called Gum Arabic (GA) to increase the solubility of GO as well as to chemically reduce it in the solution. GA functionalized GO (fGO) exhibited increased absorption in Near Infra-Red Region (NIR) which was exploited in photothermal therapy for cancer. To augment the shape and size related problems of GO (which in turn affect their rheological properties), we have conjugated them with gold nanorods (GNRs) using in situ synthesis of GO and GNRs via seed mediated method. To the above conjugate, Doxorubicin (DOX) was attached at ambient temperature (28�±2 �°C). Release kinetics of DOX with and without NIR exposure was also studied followed by in vitro photothermal killing of A549 cell lines. Enhanced NIR induced drug release as well photothermal property was observed which makes fGO@GNRs-DOX ideal for chemotherapy as well as photothermal therapy.Biography
M Shahnawaz Khan is currently a PhD student at Marine Biotechnology, National Sun Yat Sen University Kaohsiung, Taiwan. He did undergraduate in Honors Industrial Chemistry and masters in Industrial Chemistry from India’s prestigious university Aligarh M University, INDIA (2009). He is working on the hot topic like targeted drug delivery for curing cancer and employing photo-thermal method for releasing the drug at tumor region. He is concentrated on developing an effective method for wound control infection by using gold nanorods (Au NRs) and Nd-YAG laser (1064 nm) for photothermal killing Pseudomonas aeruginosa bacteria and simultaneously healing the wound infection on the (albino) mice. He is also curious to work on the brain diseases like Alzheimer, for it he synthesized the carbon nanodots and attached with Dopamine hydrochloride for efficient delivery to brain.
Email: hwu@faculty.nsysu.edu.tw
