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In Association with
Free radicals scavenging, antihyperglycemic and antihyperlipidemic activities in vegetable�s peel
6th World Congress on Biotechnology
Ambati Anusha Raju, Katta Archana, Srishti Shukla, Dommati Anand Kumar, Amtul Zehra and Ashok Kumar Tiwari
CSIR-Indian Institute of Chemical Technology, India
Posters-Accepted Abstracts: J Biotechnol Biomater
Abstract
Vegetables and their juice help in maintaining imbalance in glucose and lipid metabolism and preserving antioxidant defence, however, many times they are consumed after peeling. Role of vegetableâ��s peel in maintaining glucose and lipid metabolism and antioxidant defence is not well explored. Antioxidative, antihyperglycemic and antihyperlipidemic activity was evaluated in vitro in vegetableâ��s peel extract. Total polyphenol, flavonoid and anthocyanin content were measured. The 2, 2-diphenyl-1-picrylhydrazyl (DPPH); 2, 2-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) (ABTS.+); nitric oxide scavenging and nitroblue tetrazolium reducing, advance glycation end products (AGEs), intestinal �±-glucosidase, porcine pancreatic lipase and protein-tyrosine phosphatase 1�² (PTP 1�²) inhibitory activities were examined. Peels are rich in polyphenols, flavonoids and anthocyanins and displayed varying degrees of free radicals scavenging potentials. Extract of Luffa acutangula, Cucumis pubescens and Cucumis melo var. chito inhibited both, vesperlysine-type and pentosidine type-AGEs formation. Momordica charantia peel could inhibit only vesperlysine type-AGEs formation. Cucumis pubescens and Cucumis melo var. chito peel displayed pancreatic lipase and Momordica charantia peel, intestinal �±-glucosidase inhibitory activity. Peel extracts also displayed protein-tyrosine phosphatase 1�² (PTP 1�²) inhibitory potentials. PTP 1�² inhibitory activity was found associated with ABTS+ and DPPH radical scavenging activities. Vegetablesâ�� peels are rich source of antioxidant activities and can slow down postprandial hyperglycemia and hyperlipidemia by inhibiting intestinal �±-glucosidase and pancreatic lipase respectively. Phenomenon of insulin and leptin resistance can be tackled by their PTP 1�² inhibitory activity. Therefore, consumption of these vegetables along with peel is more healthful than consuming without peel.Biography
Email: ambati.anusha73@gmail.com katta.archana.goud@gmail.com
