Journal of Radiology
Open Access

Abstract

Introduction: Febrile seizures (FS) are always a relevant topic; thermoregulation and febrile responses, complex processes are important aspects of the unsolved puzzle. Methods: Here, FS are explored from comparative evolutionary pressure data-sets for insights/contributing factors to age dependent vulnerability and for potential MRI data acquisition for evidence-based medicine. Results: Thermoregulatory responses� evolutionary quest is for maximal performance at optimal temperature, experimentally shown for insects�/viruses� population growth and for not performance. Relying on external heat sources, ectotherms� narrow range of performance thermal sensitivities is explained by natural selection, not thermodynamics; endotherms�, birds�/mammals�, thermally constrained set-points evolved promoting heat loss, not enhancing performance. Mammalian brains� selective brain cooling (SBC) is a special evolutionary case within the thermal core because hyperthermia, causing febrile seizures, limits performance; SBC separates brain temperature (T) regulation independently from the body to keep TbrainBiography