Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 3330
Journal of Biotechnology & Biomaterials received 3330 citations as per Google Scholar report
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
Evaluation of circulatory RNA based biomarker panel in hepatocellular carcinoma
2nd World Congress on Bio Summit & Molecular Biology Expo
Ahmed Hassan Fawzi El-Tawdi
Ain Shams University, Egypt
Posters & Accepted Abstracts: J Biotechnol Biomater
Abstract
The circulating transcriptome (coding and non-coding) plays a critical role in cancer and novel accurate strategies for early detection of hepatocellular carcinoma (HCC) are strongly needed. We chose a HCC-specific RNA based biomarker panel based on the integration of differential lysosomal associated membrane protein 2 (LAMP2) gene expressions with its selected epigenetic regulators using bioinformatic methods. This was followed by RT-qPCR validation in serum of 78 patients with HCC, 36 patients with chronic hepatitis C (CHC) infection and 44 healthy volunteers. We used risk score analysis to evaluate the diagnostic efficacy of the serum profiling system. Moreover, in 20 of the 78 HCC cases involved in the study; we examined the expression of RNA based biomarker panel in both HCC and adjacent non-tumor tissues and assessed their correlation with the serum level of this panel. The 4 RNA based biomarker panel [long non-coding RNA-C terminal binding protein, androgen responsive (lncRNA-CTBP), microRNA-16-2 (miR-16-2), microRNA-21-5-P (miR-21-5p) and LAMP2 had high sensitivity and specificity for discriminating HCC from healthy controls and also from CHC patients. Among these 4 RNAs serum miR- 16-2 and miR-21-5p were independent prognostic factors. The circulatory RNA based biomarker panel can serve as a potential biomarker for HCC diagnosis and prognosis.Biography
Email: drtawdi@yahoo.com
