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In Association with
Evaluation of circulatory RNA based biomarker panel in hepatocellular carcinoma
2nd World Congress on Bio Summit & Molecular Biology Expo
Ahmed Hassan Fawzi El-Tawdi
Ain Shams University, Egypt
Posters & Accepted Abstracts: J Biotechnol Biomater
Abstract
The circulating transcriptome (coding and non-coding) plays a critical role in cancer and novel accurate strategies for early detection of hepatocellular carcinoma (HCC) are strongly needed. We chose a HCC-specific RNA based biomarker panel based on the integration of differential lysosomal associated membrane protein 2 (LAMP2) gene expressions with its selected epigenetic regulators using bioinformatic methods. This was followed by RT-qPCR validation in serum of 78 patients with HCC, 36 patients with chronic hepatitis C (CHC) infection and 44 healthy volunteers. We used risk score analysis to evaluate the diagnostic efficacy of the serum profiling system. Moreover, in 20 of the 78 HCC cases involved in the study; we examined the expression of RNA based biomarker panel in both HCC and adjacent non-tumor tissues and assessed their correlation with the serum level of this panel. The 4 RNA based biomarker panel [long non-coding RNA-C terminal binding protein, androgen responsive (lncRNA-CTBP), microRNA-16-2 (miR-16-2), microRNA-21-5-P (miR-21-5p) and LAMP2 had high sensitivity and specificity for discriminating HCC from healthy controls and also from CHC patients. Among these 4 RNAs serum miR- 16-2 and miR-21-5p were independent prognostic factors. The circulatory RNA based biomarker panel can serve as a potential biomarker for HCC diagnosis and prognosis.Biography
Email: drtawdi@yahoo.com
