ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Evaluation of antibrucella components of bovine and murine macrophages

2nd International Conference and Exhibition on Pathology

Raheela Akhtar, Yongqun Oliver He, Muhammad Faheem Afzal, Mansur ud Din Ahmad and Muhammad Younus

Accepted Abstracts: J Clin Exp Pathol

DOI: 10.4172/2161-0681.S1.010

Abstract
Brucella abortus is an intracellular pathogen of great economic importance affecting macrophages. The present study revealed that bovine and murine macrophages present a significant difference in their ability to produce various antibrucella components such as lysozyme, reactive oxygen species, reactive nitrogen intermediates and pro-inflammatory cytokines. The differential production of these components explained the differential Brucella killing ability of these species that was measured in terms of intramacrophagic survival of Brucella in murine and bovine macrophages. Key words: Bovine macrophages, Brucella abortus , Cell stimulation, Cytokines, Murine macrophages.
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