Journal of Infectious Diseases & Therapy
Open Access

Abstract

CRP is an acute phase protein secreted in the blood stream by the liver in response to inflammatory cytokines such as IL6 and several other systemic inflammation biomarkers. Since inflammatory and immune factors have a key role in the pathogenesis of vitiligo, we aimed to assess the relationship between the serum level of hs-CRP (as a marker for systemic inflammation) and the pathogenesis of vitiligo. In this case-control study, we enrolled patients with vitiligo who had referred to our Dermatology Department. The patients were divided into two groups: Those with type A vitiligo (generalized, n=30) and those with type B vitiligo (segmental, n=30). Moreover, 30 people who had the inclusion criteria and did not have vitiligo were selected among those referring to the clinic as the control group and matched with the other two groups. The serum hs-CRP levels were checked for all the patients in the three groups and compared. The serum level of hs-CRP was 4.76�±1.31 mg/l in patients with type A vitiligo, 3.71�±1.03 in those with type B vitiligo and 3.01�±1.08 in those in the control group. The mean serum hs-CRP level was significantly higher in patients with type A compared with those with type B and the control group (P<0.001). However, in patients with type B and the control groups, no significant difference was seen in this regard (P=0.053). We found an association between hs-CRP and generalized vitiligo. This association could imply that hs-CRP could intensify the severity of vitiligo.

Biography

Email: rezaghaderi@yahoo.com