Clinical Pharmacology & Biopharmaceutics
Open Access

Abstract

A new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl-2,3-dihydro-8H-pyrano[3,2]chromen-4-one together with previously reported epicatechin were isolated from the ethyl acetate soluble fraction of the methanol extract of the stem bark of Commiphora pedunculata. The structures of these compounds were elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR. The compounds were active against nine out of twelve tested microorganisms including a resistant strain; vancomycin resistant Entrococci (VRE), Escherichia coli, Staphylococcus aureus and Candida albicans. The zones of inhibition ranged between 22 and 34 mm against the microorganisms. The Minimum Inhibitory Concentration (MIC) was as low as 6.25 �?¼g/mL against Shigella dysentriae, Bacillus cereus and Staphylococcus aureus while the Minimum Bactericidal Concentration (MBC) was as low as 50 �?¼g/mL against Pseudomonas aeruginosa, VRE and Candida albicans. This is the first report of the isolation of the compound.

Biography

Nasir Tajuddeen has completed his MSc in Organic Chemistry at Ahmadu Bello University Zaria. He is currently pursuing his PhD in the same University. His focus is exploring medicinal plants for bioactive molecules that can be adopted as new therapeutic agents or that can serve as lead in drug discovery. He has published 5 papers in reputed journals.

Email: ntajuddeen@yahoo.com