Journal of Biotechnology & Biomaterials
Open Access

Abstract

Nanotechnology is currently employed as a tool to explore the darkest avenues of medical sciences in several ways like imaging, sensing, targeted drug delivery, gene delivery systems and artificial implants. Hence, nanosized organic and inorganic particles are catching increasing attention in medical applications due to their amenability to biological functionalization. Over the recent decade, gold nanoparticles (NPs) have attracted significant interest as a novel platform for various applications such as nanobiotechnology and biomedicine because of convenient surface bioconjugation with molecular probes and remarkable plasmon-resonant optical properties. The development of nanoparticle-based vectors that decrease the toxicity of free drugs and ensure targeted delivery directly to target cells..Conjugates of gold NPs with antibiotics and antibodies also have been used for selective photothermal killing of protozoa and bacteria.In the present study, biocom[patible polymer stabilized Azithromycin- gold nanoconjugate was synthesized, characterized by scanning electron microscopy, FTIR and the synthesized nanoconjugate was tested against clinical isolate of E.coli and Staphylococcus aureus .Increased spectrum of antibacterial activity was recorded in chitosan stabilized Azithromycin- gold nanoconjugate against both the tested strains. The highest increase in inhibitory zone for E.coli and Staph.aureus was observed.The present study suggests possible utilization of antibiotics ?gold nanoconjugate as an effective anti microbial agent against the pathogenic bacteria.

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