Journal of Gastrointestinal & Digestive System
Open Access

Abstract

The aim of the present study is improving prophylaxis and treatment of chronic gastroduodenal pathology in adolescents on the basis of determining clinical, endoscopic, and morphological peculiarities of said pathology. A total of 155 adolescents 11 to 18 years of age with inflammatory-destructive diseases of the upper gastrointestinal tract and Connective Tissue Disorders (CTD) were studied. The traits of the CTD, including the Marfan syndrom, were determined relying on the Ghent criteria. Morphological peculiarities are represented by high frequency of reflux-gastritis (77%) and a reduction in the level of interstitial collagens type 3 and type 1 in the lamina propria of gastric and duodenal mucosa. The form of mucosal lesions is a chronic non-atrophic (surface) gastritis with simultaneous inflammation in the antral and fundal parts. Duodenal ulcer was detected in 12% only and it was accompanied by detection of Helicobacter pylori. The connective tissue matrix of the mucosa is characterized by structural transformation of collagen fibrils (wrong orientation, focal sclerosis, immaturity). It is accompanied by decrease in a mucosa functional ability with development of the valve-sphincter failure. The role of CTD in the development of gastroduodenal pathology in puberty has been established. A genetically dependent insufficiency of interstitial collagens is a major cause of development bile reflux, which is a leading factor of gastroduodenal pathology formation in adolescents with CTD. The work provides grounds for employing in adolescents with CTD rehabilitation measures, connected with a prevention of reflux-gastritis progression and stimulation of the collagen synthesis.

Biography

Email: inna.yakovleva@amwl.lu