Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.
Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers
Google Scholar citation report
Citations : 3330
Journal of Biotechnology & Biomaterials received 3330 citations as per Google Scholar report
Indexed In
- Index Copernicus
- Google Scholar
- Sherpa Romeo
- Open J Gate
- Genamics JournalSeek
- Academic Keys
- ResearchBible
- China National Knowledge Infrastructure (CNKI)
- Access to Global Online Research in Agriculture (AGORA)
- Electronic Journals Library
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- SWB online catalog
- Virtual Library of Biology (vifabio)
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- ICMJE
Useful Links
Recommended Journals
Related Subjects
Share This Page
In Association with
Elevated expression of cytosolic phospholipase A2 delta is associated with hepatocellular carcinoma progression: Animal study validated with sera of liver cancer patients
21st European Biotechnology Congress
Maryam Ranjpour Aghmiouni and S K Jain
Jamia Hamdard University, India
ScientificTracks Abstracts: J Biotechnol Biomater
Abstract
Liver cancer is the third common cancer to cause maximum death among patients diagnosed with cancers. The search for new biomarker discovery is necessary as none of the identified biomarkers alone are enough sensitive toward hepatocellular carcinoma (HCC). In order to find out novel biomarkers that can diagnose HCC at very early stage, we have developed a rodent model using chemical carcinogens, N-Nitrosodiethylamine (DEN) and 2-aminoacetylfluorine (2AAF). The disease progression was monitored by histological evaluation. Proteomic approaches such as 2D-Electrophoresis, LCMS/MS and Western blot analyses have been used to analyze the differentially expressed proteins in carcinogen-treated animals vis-a-vis controls. The total serum proteins were isolated, solubilized and resolved on 2D-Gel Electrophoresis using broad pH range IPG strips. PD-Quest analysis revealed proteins that are differentially expressed in serum of the carcinogen-treated rats as compared to controls. Some of these proteins have been identified by LCMS/MS. Histological analysis confirmed liver inflammation and disease initiation at one month and tumorigenesis at four months after carcinogen treatment. One of the differentially expressed proteins, namely, cytosolic phospholipase A2 delta was significantly up-regulated at very early stage of cancer development and continued to remain elevated with disease progression up to tumor stage. The increase in its expression has been confirmed by Western blot analysis. Further, the analysis of serum of liver cancer patients also showed elevated expression of this protein that validated our experimental data. The study suggests that elevation in cytosolic phospholipase A2 delta expression is associated with progression of HCC.Biography
Maryam Ranjpour Aghmiouni has completed her PhD from Jamia Hamdard University. She has applied for Post-doctoral position at Illinois University and her application is under process. She has published two manuscripts and three more manuscripts are under re-revision status at high repute journals.
E-mail: maryam_o2001@yahoo.com
