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EFFECTS OF SPECIFIC CHRONIC DISEASE AND MULTI-MORBIDITY ON FUNCTIONAL DECLINE: A THREE-YEAR STUDY WITH COMMUNITY-DWELLING ELDERLY IN SHANGHAI, CHINA | 71328
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Background: The prevalence rate of functional impairment increased with age. The previous studies suggested that chronic
diseases are one of the most common causes of functional decline in the elderly. However, there are few studies focusing on the
effect of multi-morbidity on the functional impairment. The purpose of this study is to explore the effects of specific chronic
diseases and multi-morbidity on the functional decline in the aging people.
Methods: The study selected data from the 3-year (2013-2015) continuing cohort survey conducted among the community
residents aged â�?¥60 years. Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) were used to
measure the functional status. The prevalence of 11 chronic diseases was evaluated. The relationships between functional
decline at follow-up and a single chronic disease or multi-morbidity were assessed via regression analysis.
Results: In 2015, 18.5% of subjects experienced a decline in ADL, and 29.9% experienced a decline in IADL, compared with
2013. Dementia, tumour, rheumatoid arthritis, and stroke were associated with ADL or IADL decline respectively. The number
of co-occurrence chronic diseases was positively related with declines in ADL and IADL. Some combinations of two or three
chronic diseases increased the risk of functional decline in the elderly.
Conclusion: Single chronic diseases had a different impact on functional decline, and dementia was associated with the greatest
risk. Multi-morbidity increases the risk of ADL or IADL decline to varying degrees based on the number of diseases and
disease combinations. So we suggested that avoiding the co-occurrence of several chronic diseases could assist with preventing
functional decline in the elderly.
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