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Effect of thyroxin treatment on carotid intima-media thickness reduction in patients with subclinical hypothyroidism: A meta-analysis of clinical trials
Joint Event on 30th World Psychiatrists and Psychologists Meet and 3rd World Congress on Pediatric Neurology and Pediatric Surgery
Aziz M, Kandimalla Y, Machavarapu A, Saxena A, Das S, Younus A, Nguyen M, Malik R, Anugula D, Latif M A, Humayun C, Khan I M, AdusA, Rasool A, Veledar E and Nasir K
Baptist Health South Florida, USABenedictine University, USAOcala Regional Medical Center, USACreighton University Medical Center, USAFlorida International University, USAJohns Hopkins University, USA
Posters & Accepted Abstracts: J Child Adolesc Behav
Abstract
Aim: Research shows that Subclinical Hypothyroidism (SCH) is related to an increased Carotid Intima-Media Thickness (CIMT), a surrogate marker of subclinical Cardiovascular Disease (CVD). It is controversial whether or not SCH should be treated to reduce CVD morbidity and mortality. This meta-analysis aimed to determine whether SCH is associated with an increase in CIMT as compared to Euthyroidism (EU) and whether Thyroxin (T4) treatment in SCH can reverse the change in CIMT. Methods: Two independent reviewers conducted an extensive database research up to December 2016. A total of 12 clinical trials discussed the effect of Thyroxin on CIMT values at pre and post-treatment in subjects with SCH. Results: CIMT was significantly higher among SCH (n=280) as compared to EU controls (n=263) at baseline; the pooled Weighted Mean Difference (WMD) of CIMT was 0.44 mm [95% confidence interval (CI) 0.14, 0.74], p=0.004; I2=65%. After treatment with thyroxin in subjects with SCH (n=314), there was a statistically significant decrease in CIMT from pre- to post-treatment; the pooled WMD of CIMT decrease was [WMD-0.32; 95% CI (-0.47, -0.16), p=<0.0001; I2=2%], and it was no longer different from EU controls [WMD 0.13 mm; 95% CI (-0.04, 0.30); p=0.14; I2=27%]. The total cholesterol (TC), triglycerides (TG) and Low-Density Lipoprotein (LDL) were higher in SCH as compared to EU controls and decreased significantly after treatment with thyroxin. Conclusion: This meta-analysis shows that thyroxin therapy in subjects with SCH significantly decreases CIMT and improves lipid profile, modifiable CVD risk factors. Thyroid hormone replacement in subjects with SCH may play a role in slowing down or preventing the progression of atherosclerosis.Biography
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