Journal of Obesity & Weight Loss Therapy
Open Access

Abstract

Introduction: The aim of this community-based study is to ascertain the effect of different obesity phenotypes on the incidence of chronic kidney disease in Iranian adults. Methods: Subjects were adults aged â�?¥20 years who participant in Tehran Lipid Glucose Study (TLGS). All of them free from chronic kidney disease (CKD) at baseline (phase 1) and were followed up at 3 time stage (phases 2, 3 and 4) to assess risk for CKD. Subjects were stratified into 6 groups according to body mass index (BMI) and metabolic status. Having diabetes or metabolic syndrome based on NCEP ATP Ш definition, was considered dysmetabolic status. Results: CKD events occurred in 1162 participants. The prevalence of the two known obesity phenotypes (Metabolically Obese Normal Weight (MONW) and Metabolically Healthy but Obese (MHO)) in the overall population was 3.5% and 8.8% respectively. According to Kaplan-Meier curves, rates of freedom from CKD in the MHO and MONW obesity phenotypes were 75.3% and 60.6%, respectively (P<0.0001). Age and sex-adjusted (model 1) hazard ratios for participants with MHO or MONW obesity phenotype were 1.14 (95% confidence interval [CI]: 0.91-1.43) and 1.43 (CI: 1.09-1.88), respectively. After further adjustment for confounder variables (model 2), multivariate-adjusted hazard ratios for CKD for participants with MHO or MONW obesity phenotypes were 1.23 (95% confidence interval [CI]: 0.93-1.62) and 1.43 (CI: 1.08-1.90), respectively. Conclusion: Adults with the MONW obesity phenotype have higher risk for incidence of CKD; results indicate that having normal weight is not the only factor to protect against incidence of CKD.

Biography

Mottaghi A is currently Assistant Professor in Research Institute of Endocrine Sciences, Tehran, Iran. Prior to this she was a PhD student in the Department of cellular and molecular nutrition, Tehran University of Medical Sciences. She completed her PhD in 2012. She published some paper about effect of vitamin A on gene expression and study on nutritional genomics is her intests. Now, she is working on chilhood obesity and is wirting some manuscript about incidence and prevalene of chilhood obesity and outcome of this dilemma.

Email: amottaghi@sbmu.ac.ir